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High TPO Antibodies: Causes, Meaning, and What to Check NextWhen thyroid peroxidase antibody levels come back high, the result can be difficult to understand without context. TPO antibodies are immune proteins directed against thyroid peroxidase, an enzyme involved in thyroid hormone production. Elevated levels commonly occur when the immune system has developed an autoimmune response against the thyroid. Hashimoto’s thyroiditis is the most...0 Comments 0 Shares 930 Views 0 Reviews